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Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II.
Parua PK, Kalan S, Benjamin B, Sansó M, Fisher RP. Parua PK, et al. Nat Commun. 2020 Aug 28;11(1):4338. doi: 10.1038/s41467-020-18173-6. Nat Commun. 2020. PMID: 32859893 Free PMC article.
Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize to 3' and 5' ends of genes, respectively, and have overlapping but d …
Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) cata …
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.
Pirngruber J, Shchebet A, Johnsen SA. Pirngruber J, et al. Cell Cycle. 2009 Nov 15;8(22):3636-42. doi: 10.4161/cc.8.22.9890. Epub 2009 Nov 24. Cell Cycle. 2009. PMID: 19844166 Review.
This function appears to be dependent upon not only the phosphorylation of the RNA Polymerase II C-terminal domain but also upon other CDK9 targets such as the Suppressor of Ty Homolog-5 (SUPT5H), Negative Elongation Factor-E (NELF-E) and probably the human Rad6 hom …
This function appears to be dependent upon not only the phosphorylation of the RNA Polymerase II C-terminal domain but also upon other CD …
SPT5 stabilization of promoter-proximal RNA polymerase II.
Aoi Y, Takahashi YH, Shah AP, Iwanaszko M, Rendleman EJ, Khan NH, Cho BK, Goo YA, Ganesan S, Kelleher NL, Shilatifard A. Aoi Y, et al. Mol Cell. 2021 Nov 4;81(21):4413-4424.e5. doi: 10.1016/j.molcel.2021.08.006. Epub 2021 Sep 3. Mol Cell. 2021. PMID: 34480849 Free PMC article.
RPB1 degradation requires the E3 ligase Cullin 3, the unfoldase VCP/p97, and a novel form of CDK9 kinase complex. Our study demonstrates that SPT5 stabilizes RNA Pol II specifically at promoter-proximal regions, permitting RNA Pol II release from promoters into gene bodies …
RPB1 degradation requires the E3 ligase Cullin 3, the unfoldase VCP/p97, and a novel form of CDK9 kinase complex. Our study demonstra …
CRISPRi-mediated depletion of Spt4 and Spt5 reveals a role for DSIF in the control of HIV latency.
Krasnopolsky S, Novikov A, Kuzmina A, Taube R. Krasnopolsky S, et al. Biochim Biophys Acta Gene Regul Mech. 2021 Jan;1864(1):194656. doi: 10.1016/j.bbagrm.2020.194656. Epub 2020 Dec 15. Biochim Biophys Acta Gene Regul Mech. 2021. PMID: 33333262
This was accompanied by a decrease in promoter occupancy of Pol II and Cdk9, and to a lesser extent, AFF4. Interestingly, targeting the expression of one subunit of DSIF, reduced the protein stability of its counterpart partner. ...
This was accompanied by a decrease in promoter occupancy of Pol II and Cdk9, and to a lesser extent, AFF4. Interestingly, targeting t …
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Larochelle S, et al. Nat Struct Mol Biol. 2012 Nov;19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14. Nat Struct Mol Biol. 2012. PMID: 23064645 Free PMC article.
Here we show that selective inhibition of Cdk7--part of TFIIH--increases TFIIE retention, prevents DRB sensitivity-inducing factor (DSIF) recruitment and attenuates pausing in human cells. Pause release depends on Cdk9-cyclin T1 (P-TEFb); Cdk7 is also required for Cdk9 …
Here we show that selective inhibition of Cdk7--part of TFIIH--increases TFIIE retention, prevents DRB sensitivity-inducing factor (DSIF) re …
The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.
Lavoie SB, Albert AL, Handa H, Vincent M, Bensaude O. Lavoie SB, et al. J Mol Biol. 2001 Sep 28;312(4):675-85. doi: 10.1006/jmbi.2001.4991. J Mol Biol. 2001. PMID: 11575923
The efficiency to promote the dephosphorylation of both proteins matches their capacity to inhibit purified Cdk9 kinase, suggesting that Cdk9 is the major kinase phosphorylating hSpt5 and Rpb1 in vivo. We show that Cdk9 phosphorylates both the CTR1 and the CT …
The efficiency to promote the dephosphorylation of both proteins matches their capacity to inhibit purified Cdk9 kinase, suggesting t …
MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.
Estable MC, Naghavi MH, Kato H, Xiao H, Qin J, Vahlne A, Roeder RG. Estable MC, et al. J Biomed Sci. 2002 May-Jun;9(3):234-45. doi: 10.1007/BF02256070. J Biomed Sci. 2002. PMID: 12065898
Positive transcription elongation factor-b (P-TEFb) contains CDK9 and cyclin T(1). P-TEFb was affinity purified from a stably transfected cell line that expresses epitope-tagged CDK9, and proteins that appeared to be specifically bound were sequenced. In addition to …
Positive transcription elongation factor-b (P-TEFb) contains CDK9 and cyclin T(1). P-TEFb was affinity purified from a stably transfe …
Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.
Bourgeois CF, Kim YK, Churcher MJ, West MJ, Karn J. Bourgeois CF, et al. Mol Cell Biol. 2002 Feb;22(4):1079-93. doi: 10.1128/MCB.22.4.1079-1093.2002. Mol Cell Biol. 2002. PMID: 11809800 Free PMC article.
The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1. CDK9 is able to hyperphosphorylate the carboxyl- …
The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/ …
11 results